Theory

This section describes the mathematical models implemented by bindcurve, their assumptions, and the meaning of their fitted parameters.

Logistic model

The empirical inhibitory IC₅₀ model.

Logistic model

Equilibrium binding

Direct, three-state, and four-state binding models.

Equilibrium binding models

IC₅₀ to Kd

Approximate and finite-concentration conversions.

Converting IC₅₀ to K_d